In summary, our novel approach to investigating atherosclerosis in vitro through a 2D model employing immortalized immune and vascular cells holds promise for uncovering the fundamental mechanisms of atherosclerosis. Additionally, this model shows potential applicability in high-throughput drug screening endeavors.Figure 5. Establishment of an in vitro 2D coculture system.Figure 6. Establishment of an in vitro drug screening system.PerspectivesOur 2D co-culture model, based on immortalized cell types derived from WS patient-specific iPSCs, ― 248 ―
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