京都大学薬学研究科医薬創成情報科学専攻システムバイオロジー分野・准教授Abstracthomeostasis. However, the effects of aging on sleep/wakefulness regulatory mechanisms remain はじめに老化は，日々の睡眠量や睡眠構築，昼夜の睡眠量の分布など，睡眠に著しい影響を及ぼす．高齢者は，加齢とともに睡眠が分断化し，レム睡眠の減少がみられ，さらには，加齢性疾患の影響によっても不眠症状や睡眠障害が増悪する．睡眠が不足すると，日常生活への支障や免疫機能の低下が数々の疫学的研究で示されている．睡眠という生理機能が，生命活動を維持するためにも大変重要な機能で長谷川 恵美Emi HasegawaKyoto University― 220 ―Sleep undergoes structural and qualitative changes as individuals age, resulting in decreased subjective satisfaction with sleep. These age-related changes include lighter, more fragmented sleep, a reduction in deep slow-wave sleep, and difficulty maintaining sleep throughout the night. Moreover, equally importantly, chronic sleep deprivation is known to increase the risk of developing Alzheimer's disease, heart disease, diabetes, and cancer. Sleep deprivation due to aging is expected to exacerbate the risk of developing systemic chronic diseases by disrupting metabolic, immune, and cognitive unclear. The research proposal aims to investigate how aging affects neuronal populations and neural circuits involved in regulating sleep/wakefulness states. I conduct my research to uncover the factors responsible for inducing age-related sleep abnormalities by identifying alterations in neural activities and gene expressions during age. Additionally, I plan to explore the relationship between age-related sleep abnormalities and chronic inflammation, which is increasingly recognized as a contributor to age-related diseases. Ultimately, I will propose innovative ideas aimed at extending healthy lifespan through the implementation of therapeutic strategies focused on enhancing sleep quality.加齢に伴う睡眠異常発症メカニズムの探索Investigating the mechanisms of sleep disorders associated with aging
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