知症治療薬と作用機序が異なり多剤併用療法の選択肢を広げる意味で前途有為である．謝 辞本研究を遂行するにあたり，ご援助を賜りました公益財団法人 中外創薬科学財団に深く感謝申し上げます．また研究の遂行にあたり木下専教授（名古屋大学理学研究科）に温かいご指導をいただきました．この場をお借りいたしまして厚く御礼申し上げます．引用文献1. Malek-Ahmadi M: Reversion From Mild Cognitive Impairment to Normal Cognition: A Meta-Analysis. Alzheimer Dis Assoc Disord, 30(4):324-330 (2016).2. Ageta-Ishihara N, Miyata T, Ohshima C, Watanabe M, Sato Y, Hamamura Y, Higashiyama T, Mazitschek R, Bito H, Kinoshita M: Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation. Nat Commun, 4:2532 (2013).3. Ageta-Ishihara N, Yamazaki M, Konno K, Nakayama H, Abe M, Hashimoto K, Nishioka T, Kaibuchi K, Hattori S, Miyakawa T, Tanaka K, Huda F, Hirai H, Hashimoto K, Watanabe M, Sakimura K, Kinoshita M: A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance. Nat Commun, 6:10090 (2015).4. Ageta-Ishihara N, Konno K, Yamazaki M, Abe M, Sakimura K, Watanabe M, Kinoshita M: CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration. Neurochem Int, 119:190-198 (2018)5. Ageta-Ishihara N, Kinoshita M: Developmental and postdevelopmental roles of septins in the brain. Neurosci Res, 170:6-12 (2021).6. 2019 年度日本神経科学学会奨励賞7. 令和 2 年度文部科学大臣表彰若手科学者賞8. Sharma S, Quintana A, Findlay GM, Mettlen M, Baust B, Jain M, Nilsson R, Rao A, Hogan PG: An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry. Nature, 499(7457):238-42 (2013).9. Koch S, Acebron SP, Herbst J, Hatiboglu G, Niehrs C: Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation. Cell, 163(5):1225-1236 (2015). 10. Pennington K, Beasley CL, Dicker P, Fagan A, English J, Pariante CM, Wait R, Dunn MJ, Cotter DR: Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder. Mol Psychiatry, 13(12):1102-17 (2008). 11. Gozal YM, Dammer EB, Duong DM, Cheng D, Gearing M, Rees HD, Peng J, Lah JJ, Levey AI: Proteomic analysis of hippocampal dentate granule cells in frontotemporal lobar degeneration: application of laser capture technology. Front Neurol, 2:24 (2011).12. Tremblay C, François A, Delay C, Freland L, Vandal M, Bennett DA, Calon F: Association of Neuropathological Markers in the Parietal Cortex With Antemortem Cognitive Function in Persons With Mild Cognitive Impairment and Alzheimer Disease. J Neuropathol Exp Neurol, 76(2):70-88 (2017). 13. Whitworth C, Ciulli A: New class of molecule targets proteins outside cells for degradation. Nature, 584(7820):193-194 (2020).― 176 ―
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