おわりにIn patients with IHD who have low cardiac function and severe heart failure, for whom invasive treatments are not expected to be effective, it has been suggested that iPS cell-derived cardiac sphere transplantation, which are being developed as a new treatment, improve MFR, and that this effect is more pronounced when the LVEF is limited to less than 30%. NH3-PET has been shown to be a potentially useful modality for determining the effects of iPS cell-derived cardiac sphere transplantation in detail.When the number of patients increases, we plan to construct radiomics using AI and NH3-PET in order to determine the effects of iPS cell-derived cardiac sphere transplantation and create the criteria for its application.謝辞引用文献1. Nakao R, Nagao M, Yamamoto A, Fukushima K, Watanabe E, Sakai S, Hagiwara N: Papillary muscle ischemia on high-resolution cine imaging of nitrogen-13 ammonia positron emission tomography: association with myocardial flow reserve and prognosis in coronary artery disease. J Nucl Cardiol 29:293–303 (2022).2. Yamamoto A, Nagao M, Ando K, Nakao R, Fukushima K, Matsuo Y, Momose M, Sakai S, Hagiwara N: Risk stratification in coronary artery disease using NH3-PET myocardial flow reserve and CAD-RADS on coronary CT angiography. Int J Cardiovasc Imaging, 37:3335–42 (2021).3. Herzog BA, Husmann L, Valenta I, Gaemperli O, Siegrist PT, Tay FM, Burkhard N, Wyss CA, Kaufmann PA: Diagnostic value of 13N-ammonia myocardial perfusion PET: added value of myocardial flow reserve. J Nucl Med, 53:1230–4 (2012).4. Majmudar MD, Murthy VL, Shah RV, Kolli S, Mousavi N, Foster CR, Hainer J, Blankstein R, Dorbala S, Sitek A, Stevenson LW, Mehra MR, Di Carli MF: Quantification of coronary flow reserve in patients with ischaemic and non-ischaemic cardiomyopathy and its association with clinical outcomes. Eur Heart J Cardiovasc Imaging, 16:900–9 (2015).5. Yamamoto A, Nagao M, Ichihara Y, Niinami H: Utility of 13N-ammonia positron emission tomography to visualize the therapeutic effect: A case with anteroseptal myocardial infarction and implanted autologous skeletal stem cell-sheet. Circ Cardiovasc Imaging, 15:e014315 (2022).6. Kawaguchi S, Soma Y, Nakajima K, Kanazawa H, Tohyama S, Tabei R, Hirano A, Handa N, Yamada Y, Okuda S, Hishikawa S, Teratani T, Kunita S, Kishino Y, Okada M, Tanosaki S, Someya S, Morita Y, Tani H, Kawai Y, Yamazaki M, Ito A, Shibata R, Murohara T, Tabata Y, Kobayashi E, Shimizu H, Fukuda K, Fujita J: Intramyocardial transplantation of human iPS cell-derived cardiac spheroids improves cardiac function in heart failure animals. JACC Basic Transl Sci, 6: 239-254 (2021).― 146 ―This research was supported by Chugai Foundation for Innovative Drug Discovery Science (C-FINDs).
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