中外創薬 助成研究報告書2023
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島大学先端酵素学研究所 小迫英尊教授に深く感謝したします.また,本研究の遂行に際し,研究助成を賜りました公益財団法人 中外創薬科学財団に厚く御礼申し上げます.引用文献…1. Lachner, M. O'Carroll, D. Rea, S. Mechtler, K. and Jenuwein, T.: Methylation of histone H3 lysine 9 creates ― 46 ―a binding site for HP1 proteins. Nature, 410, 116-120 (2001).2. Tachibana, M. et al.: G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev., 16, 1779-1791 (2002).3. Peters, A.H. et al.: Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell, 107, 323-337 (2001).4. Matsui, T. et al.: Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET. Nature, 464, 927-931 (2010).5. Maeda, R. and Tachibana, M.: HP1 maintains protein stability of H3K9 methyltransferases and demethylases. EMBO Rep., 23, e53581 (2022).6. Kondo, Y. et al.: Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells. PLoS One, 3, e2037 (2008).7. Sun, Y. et al.: Histone methyltransferase SETDB1 is required for prostate cancer cell proliferation, migration and invasion. Asian J Androl., 16, 319-324 (2014).8. Frost, B. Hemberg, M. Lewis, J. and Feany, M.B.: Tau promotes neurodegeneration through global chromatin relaxation. Nat Neurosci., 17, 357-366 (2014).9. Ryu, H. et al.: ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease. Proc Natl Acad Sci U S A, 103, 19176-19181 (2006).10. Branon, T.C. et al.: Efficient proximity labeling in living cells and organisms with TurboID. Nat Biotechnol., 36, 880-887 (2018).11. Wang, C. et al.: MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. Sci Signal., 7, ra71 (2014).12. Sun, Y. et al.: Histone methyltransferase SETDB1 is required for prostate cancer cell proliferation, migration and invasion. Asian J Androl., 16, 319-324 (2014).13. Narita, M. et al.: Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell, 113, 703-716 (2003).

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