つことも期待される．謝 辞この研究の遂行にあたり，多大なるご支援とご助言を賜りました先生方，そして私が主宰する熊本大学国際先端医学研究機構免疫ゲノム構造学研究室のメンバーに深く感謝申し上げます．特に，横浜市立大学田村智彦博士には研究の方向性についての貴重なご助言をいただきました．また，熊本大学須田年生博士と指田吾郎博士にはBPDCNの解析において多大なご協力をいただきましたことを感謝いたします．最後になりますが，公益財団法人 中外創薬科学財団より研究助成金をご提供いただきましたことに心より感謝申し上げます．本助成金のおかげで，私たちの研究室の立ち上げおよび本研究プロジェクトを実施することができました．財団関係者の皆様ならび審査員の先生方に心からの感謝の意を表します．引用文献…1. Kurotaki D, Nakabayashi J, Nishiyama A, Sasaki H, Kawase W, Kaneko N, Ochiai K, Igarashi K, Ozato K, Suzuki Y, and Tamura T: Transcription factor IRF8 governs enhancer landscape dynamics in mononuclear phagocyte progenitors. Cell Rep, 22:2628-41 (2018).― 39 ―2. Kurotaki D, Osato N, Nishiyama A, Yamamoto M, Ban T, Sato H, Nakabayashi J, Umehara M, Miyake N, Matsumoto N, Nakazawa M, Ozato K, and Tamura T: Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation. Blood, 121:1839-49 (2013).3. Kurotaki D, Kawase W, Sasaki H, Nakabayashi J, Nishiyama A, Morse HC, 3rd, Ozato K, Suzuki Y, and Tamura T: Epigenetic control of early dendritic cell lineage specification by the transcription factor IRF8 in mice. Blood, 133:1803-13 (2019).4. Kurotaki D, Kikuchi K, Cui K, Kawase W, Saeki K, Fukumoto J, Nishiyama A, Nagamune K, Zhao K, Ozato K, Rocha PP, and Tamura T: Chromatin structure undergoes global and local reorganization during murine dendritic cell development and activation. Proc Natl Acad Sci U S A, 119:e2207009119 (2022).5. Dekker J, Marti-Renom MA, and Mirny LA: Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data. Nat Rev Genet, 14:390-403 (2013).6. Cabeza-Cabrerizo M, Cardoso A, Minutti CM, Pereira da Costa M, and Reis e Sousa C: Dendritic Cells Revisited. Annu Rev Immunol, 39:131-66 (2021).7. Kurotaki D, and Tamura T: Transcriptional and Epigenetic Regulation of Innate Immune Cell Development by the Transcription Factor, Interferon Regulatory Factor-8. J Interferon Cytokine Res, 36:433-41 (2016).8. Cuglievan B, Connors J, He J, Khazal S, Yedururi S, Dai J, Garces S, Quesada AE, Roth M, Garcia M, McCall D, Gibson A, Ragoonanan D, Petropoulos D, Tewari P, Nunez C, Mahadeo KM, Tasian SK, Lamble AJ, Pawlowska A, Hammond D, Maiti A, Haddad FG, Senapati J, Daver N, Gangat N, Konopleva M, Meshinchi S, and Pemmaraju N: Blastic plasmacytoid dendritic cell neoplasm: a comprehensive review in pediatrics, adolescents, and young adults (AYA) and an update of novel therapies. Leukemia, 37:1767-78 (2023).9. Rethnam M, Tan DQ, Tan SH, Li J, Yokomori R, Li Y, Yang H, Sanda T, and Suda T: Loss of METTL3 attenuates blastic plasmacytoid dendritic cell neoplasm response to PRMT5 inhibition via IFN signaling. Blood Adv, 6:5330-44 (2022).10. Knoepfler PS, Zhang XY, Cheng PF, Gafken PR, McMahon SB, and Eisenman RN: Myc influences global
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