DAPI/WGADAPI/aActinin29-3 (WT)9-1 (KARS)17-6 (WT)9-1 (KARS)2-1 (ATAD3 deletion)6-2 (BOLA3)2-1 (ATAD3 deletion)22-8 (ATAD3 duplication)13-8 (MT-ATP6/8)12_10 (TAZ)6-2 (BOLA3)18-5 (ACAD3)26-3 (TAZ)22-8 (ATAD3 duplicationFigure 1. Cell size of MCM-iPSC-CMs. Cell surface was stained with WGA to visualize cell size.Figure 2. Sarcomeric structure of MCM-iPSC-CMs ― 298 ―3. Calcium Handling: The calcium-handling protein SERCA2, which heavily relies on ATP in cardiomyocytes, is affected due to reduced mitochondrial function. In this MCM-iPSC-CMs cohort, hypertrophic cells exhibited abnormal or absent calcium transients in response to electrical stimulation.
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