※東京理科大学創域理工学部生命生物科学科東京理科大学理工学部応用生物科学科※Tokyo University of Science― 132 ―Epithelial-mesenchymal transition (EMT) is implicated in the onset and progression of invasive cancer and organ fibrosis, representing crucial therapeutic targets for these diseases. We have elucidated the role of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), a minor phospholipid in the plasma membrane, as a regulator of epithelial characteristics. This study aims to clarify the mechanisms by which PI(4,5)P2 controls epithelial cell characteristics and explore the potential of inhibiting EMT by targeting PI(4,5)P2 and its downstream signals. Through this research, proteins functioning in proximity to PI(4,5)P2 in epithelial cells, including cell-cell adhesion proteins and exocytosis-related proteins have been identified. Furthermore, our research revealed that PI(4,5)P2 regulates the plasma membrane localization of PARD3, potentially facilitating the transportation of epithelial cell-specific cell-cell adhesion proteins to the plasma membrane. Increasing plasma membrane PI(4,5)P2 levels and enhancing the transport of cell-cell adhesion proteins to the plasma membrane may represent novel strategies for suppressing EMT-related diseases.Abstractはじめに上皮間葉転換は，上皮細胞がその特性を失い，代わりに間葉細胞の性質を示す現象であり，このプロセスは，癌細胞が浸潤・転移する際に特に重要である．また臓器管腔内を覆う上皮細胞が上皮間葉転換によって筋線維芽細胞へ変化し，過剰な細胞外基質を産生することや，組織常在性の線維芽細胞細胞膜脂質による上皮間葉転換制御に立脚したDevelopment of tumor metastasis and organ fibrosis suppression strategies based on epithelial-mesenchymal transition regulation by plasma membrane lipid浸潤癌・臓器線維症抑制法の開発Yoshikazu Nakamura中村 由和
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